Vascular Brain Imaging Group

Probing the cerebrovascular structure and function using high-field MRI methods

The Vascular Brain Imaging group’s mission is the development of high-field MRI methods that target the cerebrovascular structure and function with high sensitivity and precision and their application in brain imaging in health and disease.

image alt


Developments encompass hardware, MRI and fMRI data acquisition methods, analysis methods, and biophysical and computational models. Applications encompass neurological and cerebrovascular diseases, neurovascular coupling, and neuroscience.

Principal investigators:

  • Jeroen Siero (PI, Scientific Manager)
    Vascular imaging methods for unravelling brain physiology regarding blood flow and oxygenation in health and disease: small vessel disease, brain tumours, and stroke. The focus is on high-resolution and fast scanning using developed state-of-the-art hardware such as insert gradient coils.

  • Jaco Zwanenburg (PI, Scientific Director)
    High-field methods targeting vascular- and intracranial fluid dynamics including brain waste clearance, for the study of cerebral small vessel disease.

  • Natalia Petridou (PI)
    High-field high-resolution functional and structural MRI, neurovascular coupling, neuroscience.

  • Alex Bhogal (PI)

Ongoing research projects

  • Predicting consequences of small vessel disease using machine learning and 7T & 3T MRI for vessel function and tissue structure assessment
  • Clinical CVR and perfusion mapping in ischemic stroke and moyamoya disease
  • Oxygen extraction fraction and perfusion mapping
  • Cerebrovascular reactivity, perfusion and oxygen extraction fraction after radiotherapy of brain tumours
  • Line-scanning for ultra-high spatiotemporal resolution functional MRI
  • Denoising strategies to improve high-resolution fMRI
  • Multi-contrast laminar fMRI (BOLD, VASO, ASL)
  • Ultra-high resolution fMRI & MRI with high density receive arrays & insert gradient
  • Laminar cerebrovascular reactivity (macro/micro-vessels) in health and dementia
  • Imaging (microscopy & MRI) and modeling of the human cortical vasculature
  • Computational modeling of the cortical vascular structure, hemodynamics, and resulting functional MRI signals
  • Characterization & modelling of somatosensory processing to tactile stimuli (Electrocorticography, fMRI, population receptive field (pRF) modeling)


Completed research projects


Our research groups